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"ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins. Protein localization to the ER often depends on certain sequences of amino acids located at the N-terminus or C-terminus. These sequences are known as signal peptides, molecular signatures, or sorting signals. The classical ER retention signal is the C-terminal KDEL sequence for lumen bound proteins and KKXX (signal sequence is located in cytoplasm) for transmembrane localization. These signals allow for retrieval from the Golgi apparatus by ER retention receptors, effectively maintaining the protein in the ER. Other mechanisms for ER retention are being studied but are not as well characterized as signal retention. ER retention receptors proteins *KDELR1 *KDELR2 *KDELR3 See also * KKXX (amino acid sequence) * KDEL (amino acid sequence) * Signal peptide *Protein targeting References "
"Bridgeland/Memorial station is a CTrain light rail in Calgary, Alberta. It serves the Northeast Line (Route 202). It opened on April 27, 1985 as part of the original Northeast line. The station is located in the median of Memorial Drive Northeast, 1.4 km from the City Hall Interlocking. A pedestrian overpass connects the station to both sides of Memorial Drive and stairs and escalators, as well as an elevator provide access down to the center-loading platform. The station serves St. Patrick's Island, which is only a short walk away, as is the Calgary Zoo, although it is also accessible via the Zoo station of the system. In 2004 and 2005 the station underwent upgrading and renovations to improve safety and access for visually impaired users wishing to access the nearby CNIB facility, and also in preparation for increased usage as work on The Bridges - a major inner city redevelopment project on the north side of the station - progresses. The station was closed for a couple of weeks in the Summer of 2004 due to the construction. As part of Calgary Transit's plan to operate 4-car trains by the end of 2014, all 3-car platforms are being extended. Construction on the extension of the platform at Bridgeland/Memorial started and was finished in 2014.http://www.calgarytransit.com/html/lrt_platform_construction.html In 2005, the station registered an average transit of 1,300 boardings per weekday. In the Media In 1993, a re-enactment of an incident involving a 4-year-old child becoming entrapped by an escalator was filmed inside the station for the CBS show "Rescue 911". The actual event occurred at Rundle LRT station but Bridgeland was chosen for having an identical layout and more aesthetically pleasing visuals. References Category:CTrain stations Category:Railway stations in Canada opened in 1985 "